SE443048B - Sett och element for bestemning av bilirubin - Google Patents
Sett och element for bestemning av bilirubinInfo
- Publication number
- SE443048B SE443048B SE7800403A SE7800403A SE443048B SE 443048 B SE443048 B SE 443048B SE 7800403 A SE7800403 A SE 7800403A SE 7800403 A SE7800403 A SE 7800403A SE 443048 B SE443048 B SE 443048B
- Authority
- SE
- Sweden
- Prior art keywords
- bilirubin
- layer
- pickling
- poly
- group
- Prior art date
Links
- BPYKTIZUTYGOLE-IFADSCNNSA-N Bilirubin Chemical compound N1C(=O)C(C)=C(C=C)\C1=C\C1=C(C)C(CCC(O)=O)=C(CC2=C(C(C)=C(\C=C/3C(=C(C=C)C(=O)N\3)C)N2)CCC(O)=O)N1 BPYKTIZUTYGOLE-IFADSCNNSA-N 0.000 claims description 262
- 238000005554 pickling Methods 0.000 claims description 63
- 239000000203 mixture Substances 0.000 claims description 40
- 239000007788 liquid Substances 0.000 claims description 37
- 238000000034 method Methods 0.000 claims description 36
- 230000007480 spreading Effects 0.000 claims description 26
- 239000000463 material Substances 0.000 claims description 22
- 238000010521 absorption reaction Methods 0.000 claims description 17
- 210000002966 serum Anatomy 0.000 claims description 17
- 239000003795 chemical substances by application Substances 0.000 claims description 15
- 229920000642 polymer Polymers 0.000 claims description 12
- 125000004432 carbon atom Chemical group C* 0.000 claims description 11
- 102000004169 proteins and genes Human genes 0.000 claims description 11
- 108090000623 proteins and genes Proteins 0.000 claims description 11
- 239000011159 matrix material Substances 0.000 claims description 10
- 230000008033 biological extinction Effects 0.000 claims description 9
- 229920001577 copolymer Polymers 0.000 claims description 8
- 238000006243 chemical reaction Methods 0.000 claims description 7
- 239000004094 surface-active agent Substances 0.000 claims description 7
- -1 alkyl methacrylates Chemical class 0.000 claims description 5
- 125000002947 alkylene group Chemical group 0.000 claims description 5
- 150000001450 anions Chemical class 0.000 claims description 5
- 125000000217 alkyl group Chemical group 0.000 claims description 4
- 239000012876 carrier material Substances 0.000 claims description 4
- 125000002091 cationic group Chemical group 0.000 claims description 4
- 125000005250 alkyl acrylate group Chemical group 0.000 claims description 3
- 125000002877 alkyl aryl group Chemical group 0.000 claims description 3
- 150000004945 aromatic hydrocarbons Chemical class 0.000 claims description 3
- 125000003710 aryl alkyl group Chemical group 0.000 claims description 3
- 125000003118 aryl group Chemical group 0.000 claims description 3
- MYRTYDVEIRVNKP-UHFFFAOYSA-N divinylbenzene Substances C=CC1=CC=CC=C1C=C MYRTYDVEIRVNKP-UHFFFAOYSA-N 0.000 claims description 3
- 230000002209 hydrophobic effect Effects 0.000 claims description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 3
- 102000053187 Glucuronidase Human genes 0.000 claims description 2
- 108010060309 Glucuronidase Proteins 0.000 claims description 2
- 125000001931 aliphatic group Chemical group 0.000 claims description 2
- 125000000962 organic group Chemical group 0.000 claims description 2
- 125000005496 phosphonium group Chemical group 0.000 claims description 2
- 239000003495 polar organic solvent Substances 0.000 claims description 2
- 125000001453 quaternary ammonium group Chemical group 0.000 claims description 2
- XFOZBWSTIQRFQW-UHFFFAOYSA-M benzyl-dimethyl-prop-2-enylazanium;chloride Chemical compound [Cl-].C=CC[N+](C)(C)CC1=CC=CC=C1 XFOZBWSTIQRFQW-UHFFFAOYSA-M 0.000 claims 2
- UDQIKPNJPDDCEL-UHFFFAOYSA-M (4-ethenylphenyl)methyl-trioctylphosphanium;chloride Chemical compound [Cl-].CCCCCCCC[P+](CCCCCCCC)(CCCCCCCC)CC1=CC=C(C=C)C=C1 UDQIKPNJPDDCEL-UHFFFAOYSA-M 0.000 claims 1
- QPXBEUHTAOWFID-UHFFFAOYSA-M benzyl-[(4-ethenylphenyl)methyl]-dimethylazanium;chloride Chemical compound [Cl-].C=1C=C(C=C)C=CC=1C[N+](C)(C)CC1=CC=CC=C1 QPXBEUHTAOWFID-UHFFFAOYSA-M 0.000 claims 1
- UTPKHMWFIPDENP-UHFFFAOYSA-M benzyl-dihexyl-oct-7-enylazanium;chloride Chemical compound [Cl-].C=CCCCCCC[N+](CCCCCC)(CCCCCC)CC1=CC=CC=C1 UTPKHMWFIPDENP-UHFFFAOYSA-M 0.000 claims 1
- 150000001768 cations Chemical group 0.000 claims 1
- 125000001183 hydrocarbyl group Chemical group 0.000 claims 1
- 239000010410 layer Substances 0.000 description 82
- 238000004458 analytical method Methods 0.000 description 32
- 238000003556 assay Methods 0.000 description 29
- 230000002452 interceptive effect Effects 0.000 description 19
- 239000000243 solution Substances 0.000 description 16
- 239000003153 chemical reaction reagent Substances 0.000 description 13
- 108010088751 Albumins Proteins 0.000 description 9
- 102000009027 Albumins Human genes 0.000 description 9
- 230000005855 radiation Effects 0.000 description 9
- 210000004369 blood Anatomy 0.000 description 8
- 239000008280 blood Substances 0.000 description 8
- 239000000126 substance Substances 0.000 description 8
- 108010010803 Gelatin Proteins 0.000 description 7
- 102000001554 Hemoglobins Human genes 0.000 description 7
- 108010054147 Hemoglobins Proteins 0.000 description 7
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 7
- 229920000159 gelatin Polymers 0.000 description 7
- 235000019322 gelatine Nutrition 0.000 description 7
- 235000011852 gelatine desserts Nutrition 0.000 description 7
- 239000008363 phosphate buffer Substances 0.000 description 7
- 238000012360 testing method Methods 0.000 description 7
- 235000021466 carotenoid Nutrition 0.000 description 6
- 150000001747 carotenoids Chemical class 0.000 description 6
- 239000008273 gelatin Substances 0.000 description 6
- 238000009304 pastoral farming Methods 0.000 description 6
- 230000004044 response Effects 0.000 description 6
- 239000011780 sodium chloride Substances 0.000 description 6
- 230000003595 spectral effect Effects 0.000 description 6
- 230000000903 blocking effect Effects 0.000 description 5
- 210000004027 cell Anatomy 0.000 description 5
- 230000003993 interaction Effects 0.000 description 5
- 229910000403 monosodium phosphate Inorganic materials 0.000 description 5
- 235000019799 monosodium phosphate Nutrition 0.000 description 5
- AJPJDKMHJJGVTQ-UHFFFAOYSA-M sodium dihydrogen phosphate Chemical compound [Na+].OP(O)([O-])=O AJPJDKMHJJGVTQ-UHFFFAOYSA-M 0.000 description 5
- 239000004793 Polystyrene Substances 0.000 description 4
- PPBRXRYQALVLMV-UHFFFAOYSA-N Styrene Chemical class C=CC1=CC=CC=C1 PPBRXRYQALVLMV-UHFFFAOYSA-N 0.000 description 4
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 description 4
- 239000013060 biological fluid Substances 0.000 description 4
- 150000001875 compounds Chemical class 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- 239000000499 gel Substances 0.000 description 4
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 3
- 108091006905 Human Serum Albumin Proteins 0.000 description 3
- 102000008100 Human Serum Albumin Human genes 0.000 description 3
- 238000002835 absorbance Methods 0.000 description 3
- OENHQHLEOONYIE-UKMVMLAPSA-N all-trans beta-carotene Natural products CC=1CCCC(C)(C)C=1/C=C/C(/C)=C/C=C/C(/C)=C/C=C/C=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C OENHQHLEOONYIE-UKMVMLAPSA-N 0.000 description 3
- 239000007864 aqueous solution Substances 0.000 description 3
- 235000013734 beta-carotene Nutrition 0.000 description 3
- 239000011648 beta-carotene Substances 0.000 description 3
- TUPZEYHYWIEDIH-WAIFQNFQSA-N beta-carotene Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CCCC1(C)C)C=CC=C(/C)C=CC2=CCCCC2(C)C TUPZEYHYWIEDIH-WAIFQNFQSA-N 0.000 description 3
- 229960002747 betacarotene Drugs 0.000 description 3
- 210000000601 blood cell Anatomy 0.000 description 3
- 230000003139 buffering effect Effects 0.000 description 3
- 230000008859 change Effects 0.000 description 3
- 125000000664 diazo group Chemical group [N-]=[N+]=[*] 0.000 description 3
- 239000004744 fabric Substances 0.000 description 3
- 239000000834 fixative Substances 0.000 description 3
- 239000002609 medium Substances 0.000 description 3
- 239000000178 monomer Substances 0.000 description 3
- 239000000049 pigment Substances 0.000 description 3
- 229920000139 polyethylene terephthalate Polymers 0.000 description 3
- 239000005020 polyethylene terephthalate Substances 0.000 description 3
- 239000002904 solvent Substances 0.000 description 3
- 238000002798 spectrophotometry method Methods 0.000 description 3
- 238000007704 wet chemistry method Methods 0.000 description 3
- OENHQHLEOONYIE-JLTXGRSLSA-N β-Carotene Chemical compound CC=1CCCC(C)(C)C=1\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C OENHQHLEOONYIE-JLTXGRSLSA-N 0.000 description 3
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
- 102000004190 Enzymes Human genes 0.000 description 2
- 108090000790 Enzymes Proteins 0.000 description 2
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 2
- 238000008050 Total Bilirubin Reagent Methods 0.000 description 2
- 238000000862 absorption spectrum Methods 0.000 description 2
- 150000001336 alkenes Chemical class 0.000 description 2
- 239000012491 analyte Substances 0.000 description 2
- 125000000732 arylene group Chemical group 0.000 description 2
- TZCXTZWJZNENPQ-UHFFFAOYSA-L barium sulfate Chemical compound [Ba+2].[O-]S([O-])(=O)=O TZCXTZWJZNENPQ-UHFFFAOYSA-L 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 230000015556 catabolic process Effects 0.000 description 2
- 229920002678 cellulose Polymers 0.000 description 2
- 239000001913 cellulose Substances 0.000 description 2
- 229920002301 cellulose acetate Polymers 0.000 description 2
- 238000006731 degradation reaction Methods 0.000 description 2
- 238000013461 design Methods 0.000 description 2
- 238000001514 detection method Methods 0.000 description 2
- 239000002612 dispersion medium Substances 0.000 description 2
- 230000005670 electromagnetic radiation Effects 0.000 description 2
- 239000012530 fluid Substances 0.000 description 2
- 230000006870 function Effects 0.000 description 2
- 150000002430 hydrocarbons Chemical group 0.000 description 2
- 230000002401 inhibitory effect Effects 0.000 description 2
- 239000011229 interlayer Substances 0.000 description 2
- 239000002736 nonionic surfactant Substances 0.000 description 2
- 150000007524 organic acids Chemical class 0.000 description 2
- 239000011148 porous material Substances 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 230000006920 protein precipitation Effects 0.000 description 2
- 238000004445 quantitative analysis Methods 0.000 description 2
- 150000003839 salts Chemical class 0.000 description 2
- 239000012898 sample dilution Substances 0.000 description 2
- 238000000926 separation method Methods 0.000 description 2
- 210000002700 urine Anatomy 0.000 description 2
- 229920002554 vinyl polymer Polymers 0.000 description 2
- QLAJNZSPVITUCQ-UHFFFAOYSA-N 1,3,2-dioxathietane 2,2-dioxide Chemical compound O=S1(=O)OCO1 QLAJNZSPVITUCQ-UHFFFAOYSA-N 0.000 description 1
- 229920000936 Agarose Polymers 0.000 description 1
- LSNNMFCWUKXFEE-UHFFFAOYSA-M Bisulfite Chemical compound OS([O-])=O LSNNMFCWUKXFEE-UHFFFAOYSA-M 0.000 description 1
- 102000004506 Blood Proteins Human genes 0.000 description 1
- 108010017384 Blood Proteins Proteins 0.000 description 1
- 108091003079 Bovine Serum Albumin Proteins 0.000 description 1
- CPELXLSAUQHCOX-UHFFFAOYSA-M Bromide Chemical compound [Br-] CPELXLSAUQHCOX-UHFFFAOYSA-M 0.000 description 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 1
- 229920002307 Dextran Polymers 0.000 description 1
- 101100298295 Drosophila melanogaster flfl gene Proteins 0.000 description 1
- 206010013710 Drug interaction Diseases 0.000 description 1
- VTLYFUHAOXGGBS-UHFFFAOYSA-N Fe3+ Chemical compound [Fe+3] VTLYFUHAOXGGBS-UHFFFAOYSA-N 0.000 description 1
- 229920000084 Gum arabic Polymers 0.000 description 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 1
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 description 1
- 229910002651 NO3 Inorganic materials 0.000 description 1
- NHNBFGGVMKEFGY-UHFFFAOYSA-N Nitrate Chemical compound [O-][N+]([O-])=O NHNBFGGVMKEFGY-UHFFFAOYSA-N 0.000 description 1
- 239000002202 Polyethylene glycol Substances 0.000 description 1
- 241000978776 Senegalia senegal Species 0.000 description 1
- 108010071390 Serum Albumin Proteins 0.000 description 1
- 102000007562 Serum Albumin Human genes 0.000 description 1
- 239000000205 acacia gum Substances 0.000 description 1
- 235000010489 acacia gum Nutrition 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 239000002671 adjuvant Substances 0.000 description 1
- 150000001338 aliphatic hydrocarbons Chemical class 0.000 description 1
- 125000000129 anionic group Chemical group 0.000 description 1
- 239000003945 anionic surfactant Substances 0.000 description 1
- 239000012736 aqueous medium Substances 0.000 description 1
- 239000012911 assay medium Substances 0.000 description 1
- 125000004429 atom Chemical group 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- 229940098773 bovine serum albumin Drugs 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 239000000969 carrier Substances 0.000 description 1
- 238000005119 centrifugation Methods 0.000 description 1
- 238000001311 chemical methods and process Methods 0.000 description 1
- 239000007795 chemical reaction product Substances 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 239000008199 coating composition Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 239000000356 contaminant Substances 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 238000009792 diffusion process Methods 0.000 description 1
- 239000003085 diluting agent Substances 0.000 description 1
- 238000003113 dilution method Methods 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 208000035475 disorder Diseases 0.000 description 1
- 239000004815 dispersion polymer Substances 0.000 description 1
- 238000006073 displacement reaction Methods 0.000 description 1
- 238000010494 dissociation reaction Methods 0.000 description 1
- 230000005593 dissociations Effects 0.000 description 1
- 239000000975 dye Substances 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000002255 enzymatic effect Effects 0.000 description 1
- 238000006911 enzymatic reaction Methods 0.000 description 1
- STVZJERGLQHEKB-UHFFFAOYSA-N ethylene glycol dimethacrylate Chemical compound CC(=C)C(=O)OCCOC(=O)C(C)=C STVZJERGLQHEKB-UHFFFAOYSA-N 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 229920001519 homopolymer Polymers 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 239000003112 inhibitor Substances 0.000 description 1
- 229910052742 iron Inorganic materials 0.000 description 1
- 239000006193 liquid solution Substances 0.000 description 1
- 230000003908 liver function Effects 0.000 description 1
- 150000002734 metacrylic acid derivatives Chemical class 0.000 description 1
- 238000010606 normalization Methods 0.000 description 1
- UYDLBVPAAFVANX-UHFFFAOYSA-N octylphenoxy polyethoxyethanol Chemical compound CC(C)(C)CC(C)(C)C1=CC=C(OCCOCCOCCOCCO)C=C1 UYDLBVPAAFVANX-UHFFFAOYSA-N 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 230000035515 penetration Effects 0.000 description 1
- 235000021110 pickles Nutrition 0.000 description 1
- 229920003213 poly(N-isopropyl acrylamide) Polymers 0.000 description 1
- 229920002401 polyacrylamide Polymers 0.000 description 1
- 229920000515 polycarbonate Polymers 0.000 description 1
- 239000004417 polycarbonate Substances 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 229920002223 polystyrene Polymers 0.000 description 1
- 229920002451 polyvinyl alcohol Polymers 0.000 description 1
- 230000003389 potentiating effect Effects 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 238000012113 quantitative test Methods 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 238000007086 side reaction Methods 0.000 description 1
- 239000012086 standard solution Substances 0.000 description 1
- 150000003431 steroids Chemical class 0.000 description 1
- SFXOHDOEOSCUCT-UHFFFAOYSA-N styrene;hydrochloride Chemical compound Cl.C=CC1=CC=CC=C1 SFXOHDOEOSCUCT-UHFFFAOYSA-N 0.000 description 1
- 150000003440 styrenes Chemical class 0.000 description 1
- 239000012085 test solution Substances 0.000 description 1
- 239000004408 titanium dioxide Substances 0.000 description 1
- JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 description 1
- YNJBWRMUSHSURL-UHFFFAOYSA-N trichloroacetic acid Chemical compound OC(=O)C(Cl)(Cl)Cl YNJBWRMUSHSURL-UHFFFAOYSA-N 0.000 description 1
- 239000001052 yellow pigment Substances 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/72—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood pigments, e.g. haemoglobin, bilirubin or other porphyrins; involving occult blood
- G01N33/728—Bilirubin; including biliverdin
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
- Y10T436/145555—Hetero-N
- Y10T436/146666—Bile pigment
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Hematology (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Urology & Nephrology (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Cell Biology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Microbiology (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US05/759,529 US4069017A (en) | 1977-01-14 | 1977-01-14 | Colorimetric assay for bilirubin |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| SE7800403L SE7800403L (sv) | 1978-07-15 |
| SE443048B true SE443048B (sv) | 1986-02-10 |
Family
ID=25055997
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SE7800403A SE443048B (sv) | 1977-01-14 | 1978-01-13 | Sett och element for bestemning av bilirubin |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US4069017A (en]) |
| JP (2) | JPS5389796A (en]) |
| BE (1) | BE862956A (en]) |
| CA (1) | CA1094432A (en]) |
| CH (1) | CH627555A5 (en]) |
| DE (1) | DE2801476C2 (en]) |
| FR (1) | FR2377632A1 (en]) |
| GB (1) | GB1591683A (en]) |
| SE (1) | SE443048B (en]) |
Families Citing this family (72)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4069017A (en) * | 1977-01-14 | 1978-01-17 | Eastman Kodak Company | Colorimetric assay for bilirubin |
| US4153668A (en) * | 1978-01-03 | 1979-05-08 | Eastman Kodak Company | Multi-zone analytical element and method using same |
| US4260392A (en) * | 1978-07-07 | 1981-04-07 | Technicon Instruments Corporation | Method and apparatus for obtaining an aliquot of a liquid in a gel medium |
| US4204839A (en) * | 1978-08-09 | 1980-05-27 | Eastman Kodak Company | Fluorimetric analysis method for bilirubin |
| US4258001A (en) * | 1978-12-27 | 1981-03-24 | Eastman Kodak Company | Element, structure and method for the analysis or transport of liquids |
| US4381921A (en) * | 1978-12-27 | 1983-05-03 | Eastman Kodak Company | Element, structure and method for the analysis or transport of liquids |
| US4288228A (en) * | 1979-01-31 | 1981-09-08 | Technicon Instruments Corporation | Whole blood analyses and diffusion apparatus therefor |
| US4274832A (en) * | 1979-02-12 | 1981-06-23 | Eastman Kodak Company | Analytical element and method for analysis of multiple analytes |
| US4311665A (en) * | 1979-07-11 | 1982-01-19 | Eastman Kodak Company | Separation and isolation of conjugated and unconjugated bilirubin |
| CA1128333A (en) * | 1979-07-11 | 1982-07-27 | Tai-Wing Wu | Determination of conjugated and unconjugated bilirubin |
| JPS5524694A (en) * | 1979-08-09 | 1980-02-21 | Eastman Kodak Co | Fluorescent analysis for bilirubin |
| US4412005A (en) * | 1979-10-25 | 1983-10-25 | Eastman Kodak Company | Determination of total bilirubin |
| US4338095A (en) * | 1980-07-11 | 1982-07-06 | Eastman Kodak Company | Method for selective determination of conjugated and unconjugated bilirubin |
| DE3029579C2 (de) * | 1980-08-05 | 1985-12-12 | Boehringer Mannheim Gmbh, 6800 Mannheim | Verfahren und Mittel zur Abtrennung von Plasma oder Serum aus Vollblut |
| US4816224A (en) * | 1980-08-05 | 1989-03-28 | Boehringer Mannheim Gmbh | Device for separating plasma or serum from whole blood and analyzing the same |
| JPS5737262A (en) * | 1980-08-19 | 1982-03-01 | Fuji Photo Film Co Ltd | Analyzing method for bilirubin and multilayer analysis material for said method |
| JPS59145965A (ja) * | 1983-02-09 | 1984-08-21 | Fuji Photo Film Co Ltd | ビリルビン定量用分析要素 |
| JPS59171864A (ja) * | 1983-03-18 | 1984-09-28 | Fuji Photo Film Co Ltd | ビリルビン定量用多層分析要素 |
| USH791H (en) | 1983-03-18 | 1990-06-05 | Harumi Katsuyama | Multilayer analytical element for quantitative analysis of bilirubin |
| JPS6014141A (ja) * | 1983-07-06 | 1985-01-24 | Kyoto Daiichi Kagaku:Kk | 多層一体化分析用具 |
| US4701411A (en) * | 1983-09-01 | 1987-10-20 | Eastman Kodak Company | Bilirubin-specific enzyme preparation, assay compositions, analytical elements and methods using same |
| DE3333720A1 (de) * | 1983-09-17 | 1985-03-28 | Bayer Ag, 5090 Leverkusen | Verfahren zum entfernen von wasser aus phosgenhaltigen organischen loesungsmitteln und neue anionenaustauscher zur durchfuehrung des verfahrens |
| US4548905A (en) * | 1984-04-09 | 1985-10-22 | Eastman Kodak Company | Reagent composition, dry element and method for determination of total bilirubin |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2854317A (en) * | 1950-08-08 | 1958-09-30 | Miles Lab | Method and composition for testing bilirubin in urine |
| AT316761B (de) * | 1971-03-05 | 1974-07-25 | Boehringer Mannheim Gmbh | Reagens zur Bestimmung von Gesamt-Bilirubin |
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| US3814586A (en) * | 1973-01-02 | 1974-06-04 | Miles Lab | Composition,method and device for determining bilirubin and urobilinogen |
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| FR2280081A1 (fr) * | 1974-07-23 | 1976-02-20 | Kodak Pathe | Produit composite unitaire pour l'analyse chimique ou biologique |
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| US4069017A (en) * | 1977-01-14 | 1978-01-17 | Eastman Kodak Company | Colorimetric assay for bilirubin |
-
1977
- 1977-01-14 US US05/759,529 patent/US4069017A/en not_active Expired - Lifetime
- 1977-12-07 CA CA292,579A patent/CA1094432A/en not_active Expired
-
1978
- 1978-01-13 FR FR7800873A patent/FR2377632A1/fr active Granted
- 1978-01-13 CH CH37978A patent/CH627555A5/fr not_active IP Right Cessation
- 1978-01-13 DE DE2801476A patent/DE2801476C2/de not_active Expired
- 1978-01-13 SE SE7800403A patent/SE443048B/sv not_active IP Right Cessation
- 1978-01-13 JP JP209678A patent/JPS5389796A/ja active Granted
- 1978-01-16 GB GB1673/78A patent/GB1591683A/en not_active Expired
- 1978-01-16 BE BE184366A patent/BE862956A/xx not_active IP Right Cessation
-
1981
- 1981-11-19 JP JP56184560A patent/JPS57160063A/ja active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| JPS6339873B2 (en]) | 1988-08-08 |
| BE862956A (fr) | 1978-07-17 |
| FR2377632B1 (en]) | 1980-07-04 |
| JPS57160063A (en) | 1982-10-02 |
| CA1094432A (en) | 1981-01-27 |
| GB1591683A (en) | 1981-06-24 |
| DE2801476C2 (de) | 1982-12-09 |
| SE7800403L (sv) | 1978-07-15 |
| CH627555A5 (fr) | 1982-01-15 |
| DE2801476A1 (de) | 1978-07-20 |
| JPS5389796A (en) | 1978-08-07 |
| JPS6222100B2 (en]) | 1987-05-15 |
| FR2377632A1 (fr) | 1978-08-11 |
| US4069017A (en) | 1978-01-17 |
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